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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1564330
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pram1
Name: PML-RARA regulated adaptor molecule 1
Acc ID: CHEBI:183083
Term: indirubin
Definition: A member of the class of indolones that is 1,3-dihydro-2H-indol-2-one substituted by a 3-oxo-1,3-dihydro-2H-indol-2-ylidene group at position 3. It is the active component of Dang Gui Long Hui Wan, which has been used in traditional Chinese medicine to treat inflammatory diseases and chronic myeloid leukemia.
Chemical ID: MESH:C027185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pram1multiple interactionsISOPram1 (Mus musculus)6480464CTD[tetraarsenic tetrasulfide co-treated with indirubin co-treated with tanshinone] results in increased ubiquitination of and results in increased degradation of PRAM1 proteinPMID:18344322
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