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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1564245
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Myl2
Name: myosin light chain 2
Acc ID: CHEBI:8093
Term: phenylephrine
Definition: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID: MESH:D010656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Myl2increases expressionEXP 6480464CTDPhenylephrine results in increased expression of MYL2 mRNAPMID:11470465
Myl2increases phosphorylationEXP 6480464CTDPhenylephrine results in increased phosphorylation of MYL2 proteinPMID:18202317
Myl2multiple interactionsEXP 6480464CTDADM protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; BQ 788 inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; MYOCD protein promotes the reaction [Phenylephrine results in increased expression of MYL2 protein]; Uridine Triphosphate inhibits the reaction [MYL2 protein promotes the reaction [Phenylephrine results in increased expression of NPPA protein]]PMID:11470465 PMID:11513749 PMID:14676212 PMID:15007106
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