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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1562975
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kdm1a
Name: lysine demethylase 1A
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kdm1adecreases expressionISOKDM1A (Homo sapiens)6480464CTDValproic Acid results in decreased expression of KDM1A mRNAPMID:19101580
Kdm1amultiple interactionsISOKDM1A (Homo sapiens)6480464CTD[Valproic Acid co-treated with arsenic trioxide] results in increased expression of KDM1A mRNA; [Valproic Acid co-treated with arsenic trioxide] results in increased expression of KDM1A proteinPMID:25815518
Kdm1amultiple interactionsISOKdm1a (Mus musculus)6480464CTDKDM1A protein affects the reaction [Valproic Acid inhibits the reaction [Dexamethasone results in decreased expression of HBEGF mRNA]]; KDM1A protein affects the reaction [Valproic Acid inhibits the reaction [Dexamethasone results in decreased expression of HES1 mRNA]]; KDM1A protein affects the reaction [Valproic Acid inhibits the reaction [Dexamethasone results in decreased expression of IGSF9 mRNA]]; KDM1A protein affects the reaction [Valproic Acid inhibits the reaction [Dexamethasone results in decreased expression of RGS16 mRNA]]PMID:27645313
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