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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1562646
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ncapg
Name: non-SMC condensin I complex, subunit G
Acc ID: CHEBI:64215
Term: 2,3-dimethoxynaphthalene-1,4-dione
Definition: A naphthoquinone that is 1,4-naphthoquinone bearing two methoxy substituents at positions 2 and 3. Redox-cycling agent that induces intracellular superoxide anion formation and, depending on the concentration, induces cell proliferation, apoptosis or necrosis. Used to study the role of ROS in cell toxicity, apoptosis, and necrosis.
Chemical ID: MESH:C063002
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:16059606480464CTD2, 3-dimethoxy-1, 4-naphthoquinone results in increased expression of NCAPG mRNA

PMID:19031421
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.