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GENE - TERM ANNOTATION REPORT

RGD ID: 1562243
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fbxl2
Name: F-box and leucine-rich repeat protein 2
Acc ID: GO:0019005
Term: SCF ubiquitin ligase complex
Definition: A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
Definition Source(s): PMID:15571813, PMID:15688063
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fbxl2part_ofISOFBXL2 (Homo sapiens)1624291RGD PMID:23604317 PMID:26037928

PMID:23604317 PMID:26037928
Fbxl2part_ofIBAFB:FBgn0038385 or MGI:3052506 or PANTHER:PTN002547163 or SGD:S000002714 or SGD:S000004344 or TAIR:locus:2027082 or TAIR:locus:2102400 or TAIR:locus:2145512 or TAIR:locus:2149805 or UniProtKB:Q5VMP0 or UniProtKB:Q9H469 or UniProtKB:Q9UJT9 or UniProtKB:Q9UKA1 or ZFIN:ZDB-GENE-030131-3556 or ZFIN:ZDB-GENE-030131-59201600115GO_CentralGO_REF:0000033

GO_REF:0000033
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