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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1561797
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cks1b
Name: CDC28 protein kinase regulatory subunit 1B
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cks1baffects expressionISOCks1b (Mus musculus)6480464CTDEstradiol affects the expression of CKS1B mRNAPMID:15598610
Cks1bdecreases expressionISOCKS1B (Homo sapiens)6480464CTDEstradiol results in decreased expression of CKS1B mRNAPMID:11179685 PMID:17622325 PMID:23019147
Cks1bincreases expressionISOCKS1B (Homo sapiens)6480464CTDEstradiol results in increased expression of CKS1B mRNA; Estradiol results in increased expression of CKS1B proteinPMID:16474171 PMID:18556351 PMID:19167446 PMID:23029392
Cks1bmultiple interactionsISOCKS1B (Homo sapiens)6480464CTD3,3'-diindolylmethane promotes the reaction [Estradiol results in decreased expression of CKS1B mRNA]; [Progesterone co-treated with Estradiol] results in decreased expression of CKS1B protein; Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of CKS1B mRNA]PMID:11179685 PMID:23029392
Cks1bmultiple interactionsISOCks1b (Mus musculus)6480464CTD[Estradiol co-treated with Progesterone] results in increased expression of CKS1B mRNAPMID:18556351
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