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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1561588
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dock8
Name: dedicator of cytokinesis 8
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dock8decreases expressionISODOCK8 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of DOCK8 mRNAPMID:23179753 PMID:26272509
Dock8increases methylationISODOCK8 (Homo sapiens)6480464CTDValproic Acid results in increased methylation of DOCK8 genePMID:29154799
Dock8multiple interactionsISODOCK8 (Homo sapiens)6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DOCK8 mRNAPMID:27188386
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