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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1560637
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Klrc3
Name: killer cell lectin like receptor C3
Acc ID: CHEBI:8772
Term: raloxifene
Definition: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.
Chemical ID: MESH:D020849
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Klrc3increases expressionISOKLRC3 (Homo sapiens)6480464CTDRaloxifene Hydrochloride results in increased expression of KLRC3 mRNAPMID:17395694
Klrc3multiple interactionsISOKLRC3 (Homo sapiens)6480464CTD[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KLRC3 mRNA; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of KLRC3 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of KLRC3 mRNA]; Raloxifene Hydrochloride promotes the reaction [ESR1 protein binds to KLRC3 gene]; Raloxifene Hydrochloride promotes the reaction [NCOA3 protein binds to KLRC3 gene]PMID:17395694 PMID:19059307
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