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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1560637
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Klrc3
Name: killer cell lectin like receptor C3
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Klrc3multiple interactionsEXP 6480464CTD[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of KLRC3 mRNAPMID:32741896
Klrc3increases expressionISOKLRC3 (Homo sapiens)6480464CTDEstradiol results in increased expression of KLRC3 mRNAPMID:17395694
Klrc3multiple interactionsISOKLRC3 (Homo sapiens)6480464CTD[Estradiol co-treated with TGFB1 protein] results in decreased expression of KLRC3 mRNA; [Progesterone co-treated with Estradiol] results in decreased expression of KLRC3 mRNA; CEBPB protein affects the reaction [Estradiol results in increased expression of KLRC3 mRNA]; ESR1 protein affects the reaction [Estradiol results in increased expression of KLRC3 mRNA]; Estradiol promotes the reaction [ESR1 protein binds to KLRC3 gene]; Estradiol promotes the reaction [NCOA2 protein binds to KLRC3 gene]; Estradiol promotes the reaction [NCOA3 protein binds to KLRC3 gene]; HSF2 protein affects the reaction [Estradiol results in increased expression of KLRC3 mRNA]; JUN protein affects the reaction [Estradiol results in increased expression of KLRC3 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of KLRC3 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of KLRC3 mRNA]PMID:17395694 PMID:17404688 PMID:30165855
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