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GENE - TERM ANNOTATION REPORT

RGD ID: 1560603
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map3k15
Name: mitogen-activated protein kinase kinase kinase 15
Acc ID: GO:0038066
Term: p38MAPK cascade
Definition: A MAPK cascade containing at least the p38MAPK (MAPK14) MAP kinase, or Hog1 in yeast. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of p38MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The p38MAPK cascade is activated by stress signals, including hyperosmolarity, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.
Definition Source(s): PMID:20811974, PMID:23125017, PMID:32794416
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map3k15involved_inIBAMGI:1346876 or PANTHER:PTN000172316 or SGD:S000004354 or WB:WBGene000038221600115GO_CentralGO_REF:0000033

GO_REF:0000033
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