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GENE - TERM ANNOTATION REPORT

RGD ID: 1560340
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ercc4
Name: ERCC excision repair 4, endonuclease catalytic subunit
Acc ID: GO:0006281
Term: DNA repair
Definition: The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
Definition Source(s): PMID:11563486
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ercc4acts_upstream_of_or_withinISOErcc4 (Mus musculus)1624291RGDMGI:3028660 PMID:14729965

PMID:14729965
Ercc4involved_inISOERCC4 (Homo sapiens)1624291RGDUniProtKB:Q15554 PMID:17055345 PMID:19596235

PMID:17055345 PMID:19596235
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