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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1559857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ahrr
Name: aryl-hydrocarbon receptor repressor
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of AHRR, Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA

PMID:17069994, PMID:18990726, PMID:21215274, PMID:22808131, PMID:23859880, PMID:23871856, PMID:24136580, PMID:24355419, PMID:26232522, PMID:27590929, PMID:28433708, PMID:29738842
multiple interactionsEXP 6480464CTDAHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA], Tetrachlorodibenzodioxin promotes the reaction [AHRR protein binds to BRCA1 promoter]

PMID:23859880, PMID:24136580, PMID:27590929
affects expressionISORGD:15570536480464CTDTetrachlorodibenzodioxin affects the expression of AHRR mRNA

PMID:21570461, PMID:25703434, PMID:26377647
decreases expressionISORGD:13486416480464CTDTetrachlorodibenzodioxin results in decreased expression of AHRR protein

PMID:30096437
increases expressionISORGD:13486416480464CTDTetrachlorodibenzodioxin results in increased expression of AHRR mRNA, Tetrachlorodibenzodioxin results in increased expression of AHRR protein

PMID:12655030, PMID:16426572, PMID:17234337, PMID:17517823, PMID:17599377, PMID:18089838, PMID:20106945, PMID:20702590, PMID:21493753, PMID:21632981, PMID:21998131, PMID:22903824, PMID:24472611, PMID:24806346, PMID:25654323, PMID:27783115, PMID:29704546, PMID:29738842, PMID:30203000
increases expressionISORGD:15570536480464CTDTetrachlorodibenzodioxin results in increased expression of AHRR mRNA, Tetrachlorodibenzodioxin results in increased expression of AHRR protein

PMID:12520768, PMID:14575644, PMID:15591033, PMID:15652763, PMID:16102516, PMID:16120747, PMID:16556773, PMID:17035482, PMID:17975115, PMID:19933214, PMID:20159946, PMID:20702590, PMID:20729464, PMID:20819909, PMID:20935161, PMID:21131560, PMID:21979172, PMID:22430074, PMID:22491429, PMID:22749964, PMID:24806346, PMID:25795401, PMID:26290441, PMID:28836330, PMID:29043426, PMID:29445839, PMID:29673856, PMID:29738842, PMID:29873790, PMID:30790002
multiple interactionsISORGD:13486416480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA], AHRR inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein], Arecoline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA], CL 075 promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA], KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA], N-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA], Tetrachlorodibenzodioxin promotes the reaction [AHRR protein binds to CYP1A1 gene], Tetrachlorodibenzodioxin promotes the reaction [AHRR protein binds to CYP1B1 gene], Tetrachlorodibenzodioxin promotes the reaction [AHRR protein binds to MAP2K7 gene], Tetrachlorodibenzodioxin promotes the reaction [AHRR protein binds to PNPO gene], Tetrachlorodibenzodioxin promotes the reaction [AHRR protein binds to RPL22 gene], Tetrachlorodibenzodioxin promotes the reaction [AHRR protein binds to XRCC6 gene], TIPARP mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA]

PMID:17234337, PMID:18089838, PMID:21256203, PMID:21493753, PMID:24806346, PMID:27783115, PMID:28681081, PMID:29704546, PMID:29738842
multiple interactionsISORGD:15570536480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of AHRR mRNA, [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of AHRR mRNA, actein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR protein], AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA], AHRR gene mutant form promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 gene]], AHRR gene mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA], AHRR gene mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA], AHRR protein affects the reaction [Tetrachlorodibenzodioxin results in increased activity of GPT protein], AHRR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL14 mRNA], AHRR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL2 mRNA], AHRR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL3 mRNA], AHRR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL5 mRNA], AHRR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA], AHRR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein], AHRR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B mRNA], AHRR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B protein], AHRR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of IL6 mRNA], AHRR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA], AHRR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of TNF mRNA], AHRR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR mRNA], ARNT affects the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA], Bucladesine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA], Tetrachlorodibenzodioxin inhibits the reaction [AHRR gene mutant form results in increased expression of AHR mRNA], Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to AHRR gene], TIPARP gene mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA], tributyltin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA]

PMID:16214954, PMID:18385208, PMID:20819909, PMID:20935161, PMID:21979172, PMID:22749964, PMID:24806346, PMID:25975270, PMID:26862745, PMID:28836330, PMID:29873790, PMID:30790002
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.