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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1559716
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ern1
Name: endoplasmic reticulum to nucleus signaling 1
Acc ID: CHEBI:9516
Term: thapsigargin
Definition: An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.
Chemical ID: MESH:D019284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ern1increases expressionEXP 6480464CTDThapsigargin results in increased expression of ERN1 proteinPMID:23885834
Ern1increases phosphorylationEXP 6480464CTDThapsigargin results in increased phosphorylation of ERN1 proteinPMID:24638036
Ern1affects splicingISOERN1 (Homo sapiens)6480464CTDThapsigargin affects the splicing of ERN1 mRNAPMID:27587023
Ern1increases expressionISOERN1 (Homo sapiens)6480464CTDThapsigargin results in increased expression of ERN1 mRNA; Thapsigargin results in increased expression of ERN1 protein; Thapsigargin results in increased expression of ERN1 protein modified formPMID:17963750 PMID:19139269 PMID:22378314 PMID:23885834 PMID:24224909 PMID:30796460 PMID:32535746
Ern1increases phosphorylationISOErn1 (Mus musculus)6480464CTDThapsigargin results in increased phosphorylation of ERN1 proteinPMID:20493918 PMID:23576437
Ern1increases phosphorylationISOERN1 (Homo sapiens)6480464CTDThapsigargin results in increased phosphorylation of ERN1 proteinPMID:23576437 PMID:26264395 PMID:35033536
Ern1multiple interactionsISOErn1 (Mus musculus)6480464CTD1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein]; [Thapsigargin co-treated with HRAS protein] results in increased expression of ERN1 protein; Apigenin inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein]; Thapsigargin inhibits the reaction [7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein]]PMID:20493918 PMID:23576437 PMID:24898257 PMID:29414781
Ern1multiple interactionsISOERN1 (Homo sapiens)6480464CTD1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of ERN1 protein]; [Thapsigargin affects the splicing of ERN1 mRNA] which results in increased expression of ERN1 protein alternative form; BCL2L1 protein inhibits the reaction [Thapsigargin results in increased expression of ERN1 protein]; demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein]; EUK-134 inhibits the reaction [Thapsigargin results in increased expression of ERN1 protein]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of and results in increased phosphorylation of ERN1 protein]; Thapsigargin results in increased expression of and results in increased phosphorylation of ERN1 proteinPMID:23576437 PMID:23885834 PMID:26264395 PMID:27587023 PMID:32407927
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