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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1559552
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Med1
Name: mediator complex subunit 1
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Med1increases localizationISOMed1 (Mus musculus)6480464CTDPhenobarbital results in increased localization of MED1 proteinPMID:16109766
Med1increases response to substanceISOMed1 (Mus musculus)6480464CTDMED1 gene mutant form results in increased susceptibility to PhenobarbitalPMID:16109766
Med1multiple interactionsISOMed1 (Mus musculus)6480464CTDMED1 protein promotes the reaction [Phenobarbital results in increased expression of CYP1A2 mRNA]; MED1 protein promotes the reaction [Phenobarbital results in increased expression of CYP2B10 mRNA]; MED1 protein promotes the reaction [Phenobarbital results in increased expression of CYP3A11 mRNA]; MED1 protein promotes the reaction [Phenobarbital results in increased localization of and results in increased activity of NR1I3 protein]PMID:16109766
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