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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1558608
Species: Mus musculus
RGD Object: Gene
Symbol: Cbl
Name: Casitas B-lineage lymphoma
Acc ID: CHEBI:5132
Term: flutamide
Definition: A (trifluoromethyl)benzene that has formula C11H11F3N2O3.
Chemical ID: MESH:D005485
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cblaffects expressionEXP 6480464CTDFlutamide affects the expression of CBL mRNAPMID:16301331
Cblmultiple interactionsEXP 6480464CTD[CBL protein affects the susceptibility to Flutamide] which affects the expression of BIRC3 mRNA; [CBL protein affects the susceptibility to Flutamide] which affects the expression of BIRC3 protein; CBL protein affects the reaction [Flutamide results in increased activity of CASP9 protein]; CBL protein affects the reaction [Flutamide results in increased expression of BCL2L11 protein]; CBL protein affects the reaction [Flutamide results in increased expression of DIABLO protein]; Flutamide inhibits the reaction [CBL protein affects the expression of DIABLO protein]PMID:16301331
Cbldecreases expressionISOCbl (Rattus norvegicus)6480464CTDFlutamide results in decreased expression of CBL mRNAPMID:16301331
Cblmultiple interactionsISOCbl (Rattus norvegicus)6480464CTDFlutamide results in decreased expression of and results in decreased phosphorylation of CBL proteinPMID:16301331
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