GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2b10 | increases expression | EXP | | 6480464 | CTD | Cyclophosphamide results in increased expression of CYP2B10 mRNA | PMID:24819615 | Cyp2b10 | affects hydroxylation | ISO | CYP2B6 (Homo sapiens) | 6480464 | CTD | CYP2B6 intron polymorphism affects the hydroxylation of Cyclophosphamide; CYP2B6 promoter polymorphism affects the hydroxylation of Cyclophosphamide | PMID:17502835 | Cyp2b10 | increases activity | ISO | Cyp2b3 (Rattus norvegicus) | 6480464 | CTD | CYP2B6 protein results in increased activity of Cyclophosphamide | PMID:11723234 | Cyp2b10 | increases hydroxylation | ISO | CYP2B6 (Homo sapiens) | 6480464 | CTD | CYP2B6 protein results in increased hydroxylation of Cyclophosphamide | PMID:12872138 PMID:16183265 PMID:17502835 | Cyp2b10 | increases metabolic processing | ISO | CYP2B6 (Homo sapiens) | 6480464 | CTD | CYP2B6 protein results in increased metabolism of Cyclophosphamide | PMID:15769884 PMID:18212249 PMID:18633247 PMID:24819615 | Cyp2b10 | increases response to substance | ISO | CYP2B6 (Homo sapiens) | 6480464 | CTD | CYP2B6 protein results in increased susceptibility to Cyclophosphamide; CYP2B6 results in increased susceptibility to Cyclophosphamide | PMID:11389073 PMID:12498089 PMID:9766669 | Cyp2b10 | multiple interactions | ISO | CYP2B6 (Homo sapiens) | 6480464 | CTD | [Cyclophosphamide results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; [Doxorubicin co-treated with Cyclophosphamide] affects the expression of CYP2B6 mRNA; Cyclophosphamide results in decreased expression of and results in decreased activity of CYP2B6 protein; CYP2B6 protein polymorphism affects the activity of and affects the susceptibility to Cyclophosphamide; CYP2B6 protein results in increased metabolism of and results in increased susceptibility to Cyclophosphamide; POR promotes the reaction [CYP2B6 results in increased susceptibility to Cyclophosphamide]; POR protein promotes the reaction [CYP2B6 protein results in increased susceptibility to Cyclophosphamide] | PMID:10919648 PMID:12872138 PMID:15248218 PMID:16322899 PMID:17041008 PMID:25860621 PMID:9766669 | | ||||||||||||||||||||||
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