GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2b10 | increases expression | EXP | | 6480464 | CTD | Benzo(a)pyrene results in increased expression of CYP2B10 mRNA; Benzo(a)pyrene results in increased expression of CYP2B10 protein | PMID:22228805 PMID:32417428 PMID:34472326 | Cyp2b10 | multiple interactions | EXP | | 6480464 | CTD | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of CYP2B10 mRNA] | PMID:22228805 | Cyp2b10 | affects expression | ISO | CYP2B6 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene affects the expression of CYP2B6 mRNA | PMID:20106945 | Cyp2b10 | affects methylation | ISO | CYP2B6 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene affects the methylation of CYP2B6 exon | PMID:27901495 | Cyp2b10 | decreases expression | ISO | CYP2B6 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of CYP2B6 mRNA | PMID:32234424 | Cyp2b10 | increases expression | ISO | CYP2B6 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of CYP2B6 mRNA | PMID:15735009 | Cyp2b10 | increases methylation | ISO | CYP2B6 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased methylation of CYP2B6 3' UTR; Benzo(a)pyrene results in increased methylation of CYP2B6 promoter | PMID:27901495 | Cyp2b10 | increases mutagenesis | ISO | CYP2B6 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased mutagenesis of CYP2B6 gene | PMID:25435355 | Cyp2b10 | multiple interactions | ISO | CYP2B6 (Homo sapiens) | 6480464 | CTD | [Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of CYP2B6 mRNA; [fluoranthene co-treated with Benzo(a)pyrene] inhibits the reaction [pyrene results in increased expression of CYP2B6 mRNA]; [pyrene co-treated with Benzo(a)pyrene] inhibits the reaction [fluoranthene results in increased expression of CYP2B6 mRNA]; Benzo(a)pyrene inhibits the reaction [fluoranthene results in increased expression of CYP2B6 mRNA]; Benzo(a)pyrene inhibits the reaction [pyrene results in increased expression of CYP2B6 mRNA] | PMID:17690111 PMID:33249052 | |
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