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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1558311
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2b10
Name: cytochrome P450, family 2, subfamily b, polypeptide 10
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2b10increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of CYP2B10 mRNA; Benzo(a)pyrene results in increased expression of CYP2B10 proteinPMID:22228805 PMID:32417428 PMID:34472326
Cyp2b10multiple interactionsEXP 6480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of CYP2B10 mRNA]PMID:22228805
Cyp2b10affects expressionISOCYP2B6 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the expression of CYP2B6 mRNAPMID:20106945
Cyp2b10affects methylationISOCYP2B6 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of CYP2B6 exonPMID:27901495
Cyp2b10decreases expressionISOCYP2B6 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of CYP2B6 mRNAPMID:32234424
Cyp2b10increases expressionISOCYP2B6 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of CYP2B6 mRNAPMID:15735009
Cyp2b10increases methylationISOCYP2B6 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of CYP2B6 3' UTR; Benzo(a)pyrene results in increased methylation of CYP2B6 promoterPMID:27901495
Cyp2b10increases mutagenesisISOCYP2B6 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of CYP2B6 genePMID:25435355
Cyp2b10multiple interactionsISOCYP2B6 (Homo sapiens)6480464CTD[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of CYP2B6 mRNA; [fluoranthene co-treated with Benzo(a)pyrene] inhibits the reaction [pyrene results in increased expression of CYP2B6 mRNA]; [pyrene co-treated with Benzo(a)pyrene] inhibits the reaction [fluoranthene results in increased expression of CYP2B6 mRNA]; Benzo(a)pyrene inhibits the reaction [fluoranthene results in increased expression of CYP2B6 mRNA]; Benzo(a)pyrene inhibits the reaction [pyrene results in increased expression of CYP2B6 mRNA]PMID:17690111 PMID:33249052
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