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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1558311
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2b10
Name: cytochrome P450, family 2, subfamily b, polypeptide 10
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2b10decreases expressionEXP 6480464CTDProgesterone results in decreased expression of CYP2B10 mRNAPMID:11075820
Cyp2b10increases expressionEXP 6480464CTDProgesterone results in increased expression of CYP2B10 mRNAPMID:7771797
Cyp2b10increases expressionISOCYP2B6 (Homo sapiens)6480464CTDProgesterone results in increased expression of CYP2B6 mRNAPMID:22837389
Cyp2b10multiple interactionsISOCYP2B6 (Homo sapiens)6480464CTD[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; [Progesterone co-treated with Estradiol] inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]; NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]]; NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]]; Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; Progesterone inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]PMID:21768169
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