GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sox2 | decreases expression | ISO | SOX2 (Homo sapiens) | 6480464 | CTD | cobaltous chloride results in decreased expression of SOX2 mRNA | PMID:20105288 | Sox2 | increases expression | ISO | SOX2 (Homo sapiens) | 6480464 | CTD | cobaltous chloride results in increased expression of SOX2 protein | PMID:24842335 | Sox2 | multiple interactions | ISO | SOX2 (Homo sapiens) | 6480464 | CTD | [EPAS1 protein results in increased susceptibility to cobaltous chloride] which results in increased expression of SOX2 mRNA; [HIF1A protein results in increased susceptibility to cobaltous chloride] which results in increased expression of SOX2 mRNA; triptolide inhibits the reaction [cobaltous chloride results in increased expression of SOX2 protein] | PMID:24842335 PMID:25805230 | |
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