GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sox2 | decreases expression | ISO | SOX2 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of SOX2 mRNA | PMID:24685274 PMID:33634982 | Sox2 | decreases response to substance | ISO | SOX2 (Homo sapiens) | 6480464 | CTD | SOX2 protein results in decreased susceptibility to Arsenic Trioxide | PMID:21703238 | Sox2 | increases expression | ISO | SOX2 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of SOX2 mRNA; Arsenic Trioxide results in increased expression of SOX2 protein | PMID:29396848 PMID:29486283 | Sox2 | multiple interactions | ISO | SOX2 (Homo sapiens) | 6480464 | CTD | 4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propionylamino)phenyl)butyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]; [Arsenic Trioxide co-treated with Tretinoin] results in decreased expression of SOX2 protein; Arsenic Trioxide promotes the reaction [MSI1 protein results in increased expression of SOX2 protein]; Celecoxib inhibits the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]; Dinoprostone inhibits the reaction [Celecoxib inhibits the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]]; EIF2AK2 protein affects the reaction [Arsenic Trioxide promotes the reaction [MSI1 protein results in increased expression of SOX2 protein]]; EIF2AK2 protein affects the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]; EIF2S1 protein affects the reaction [Arsenic Trioxide promotes the reaction [MSI1 protein results in increased expression of SOX2 protein]]; Etodolac inhibits the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]; MSI1 protein affects the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]; PTGS2 protein affects the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]; SOX2 protein affects the reaction [Arsenic Trioxide results in decreased susceptibility to Cisplatin]; SOX2 protein affects the reaction [Arsenic Trioxide results in increased expression of CD24 protein]; SOX2 protein affects the reaction [Arsenic Trioxide results in increased expression of NANOG protein]; SOX2 protein affects the reaction [Arsenic Trioxide results in increased expression of POU5F1 protein]; SOX2 protein affects the reaction [Arsenic Trioxide results in increased expression of PROM1 protein]; SOX2 protein affects the reaction [PTGS2 protein affects the reaction [Arsenic Trioxide results in increased expression of NANOG protein]]; SOX2 protein affects the reaction [PTGS2 protein affects the reaction [Arsenic Trioxide results in increased expression of POU5F1 protein]]; SOX2 protein affects the reaction [PTGS2 protein affects the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]] | PMID:29396848 PMID:29486283 PMID:30093655 | |
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