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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1558014
Species: Mus musculus
RGD Object: Gene
Symbol: Sox2
Name: SRY (sex determining region Y)-box 2
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sox2decreases expressionISOSOX2 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of SOX2 mRNAPMID:24685274 PMID:33634982
Sox2decreases response to substanceISOSOX2 (Homo sapiens)6480464CTDSOX2 protein results in decreased susceptibility to Arsenic TrioxidePMID:21703238
Sox2increases expressionISOSOX2 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of SOX2 mRNA; Arsenic Trioxide results in increased expression of SOX2 proteinPMID:29396848 PMID:29486283
Sox2multiple interactionsISOSOX2 (Homo sapiens)6480464CTD4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propionylamino)phenyl)butyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]; [Arsenic Trioxide co-treated with Tretinoin] results in decreased expression of SOX2 protein; Arsenic Trioxide promotes the reaction [MSI1 protein results in increased expression of SOX2 protein]; Celecoxib inhibits the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]; Dinoprostone inhibits the reaction [Celecoxib inhibits the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]]; EIF2AK2 protein affects the reaction [Arsenic Trioxide promotes the reaction [MSI1 protein results in increased expression of SOX2 protein]]; EIF2AK2 protein affects the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]; EIF2S1 protein affects the reaction [Arsenic Trioxide promotes the reaction [MSI1 protein results in increased expression of SOX2 protein]]; Etodolac inhibits the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]; MSI1 protein affects the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]; PTGS2 protein affects the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]; SOX2 protein affects the reaction [Arsenic Trioxide results in decreased susceptibility to Cisplatin]; SOX2 protein affects the reaction [Arsenic Trioxide results in increased expression of CD24 protein]; SOX2 protein affects the reaction [Arsenic Trioxide results in increased expression of NANOG protein]; SOX2 protein affects the reaction [Arsenic Trioxide results in increased expression of POU5F1 protein]; SOX2 protein affects the reaction [Arsenic Trioxide results in increased expression of PROM1 protein]; SOX2 protein affects the reaction [PTGS2 protein affects the reaction [Arsenic Trioxide results in increased expression of NANOG protein]]; SOX2 protein affects the reaction [PTGS2 protein affects the reaction [Arsenic Trioxide results in increased expression of POU5F1 protein]]; SOX2 protein affects the reaction [PTGS2 protein affects the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]]PMID:29396848 PMID:29486283 PMID:30093655
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