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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1557923
Species: Mus musculus
RGD Object: Gene
Symbol: Atr
Name: ataxia telangiectasia and Rad3 related
Acc ID: CHEBI:9763
Term: trovafloxacin
Definition: A 1,8-naphthyridine derivative that is 4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid bearing additional 2,4-difluorophenyl, fluoro and 6-amino-3-azabicyclo[3.1.0]hex-3-yl substituents at positions 1, 6 and 7 respectively. A broad-spectrum antibiotic that was withdrawn from the market due to risk of liver failure.
Chemical ID: MESH:C080163
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13140476480464CTD4-cyclohexylmethoxy-5-nitrosopyrimidine-2, 6-diamine inhibits the reaction [[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of ATR protein], 4-cyclohexylmethoxy-5-nitrosopyrimidine-2, 6-diamine inhibits the reaction [trovafloxacin results in increased phosphorylation of ATR protein], [trovafloxacin co-treated with TNF protein] results in increased phosphorylation of and results in increased activity of ATR protein, trovafloxacin results in increased phosphorylation of and results in increased activity of ATR protein, U 0126 inhibits the reaction [trovafloxacin results in increased activity of ATR protein]

PMID:25748550
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.