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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1557923
Species: Mus musculus
RGD Object: Gene
Symbol: Atr
Name: ataxia telangiectasia and Rad3 related
Acc ID: CHEBI:44423
Term: hydroxyurea
Definition: A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease.
Chemical ID: MESH:D006918
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13140476480464CTD[4-cyclohexylmethoxy-5-nitrosopyrimidine-2, 6-diamine results in decreased activity of ATR] which results in increased susceptibility to Hydroxyurea, Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]]

PMID:18158334, PMID:21730979
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.