Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	1557923
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Atr
Name:	ataxia telangiectasia and Rad3 related

Acc ID:	CHEBI:27899
Term:	cisplatin
Definition:	A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID:	MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Atr	decreases expression	EXP		6480464	CTD	Cisplatin results in decreased expression of ATR mRNA	PMID:24865317
Atr	increases phosphorylation	EXP		6480464	CTD	Cisplatin results in increased phosphorylation of ATR protein	PMID:22006019
Atr	multiple interactions	EXP		6480464	CTD	[Cisplatin co-treated with Lutein] results in decreased expression of ATR mRNA; [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Cisplatin results in increased expression of BSCL2 mRNA]; [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein]; [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Cisplatin results in increased phosphorylation of TRP53 protein]	PMID:22003191 PMID:24865317
Atr	decreases expression	ISO	ATR (Homo sapiens)	6480464	CTD	Cisplatin results in decreased expression of ATR mRNA	PMID:27594783
Atr	decreases response to substance	ISO	ATR (Homo sapiens)	6480464	CTD	ATR results in decreased susceptibility to Cisplatin	PMID:21652733
Atr	increases activity	ISO	ATR (Homo sapiens)	6480464	CTD	Cisplatin results in increased activity of ATR protein	PMID:21324906
Atr	increases expression	ISO	Atr (Rattus norvegicus)	6480464	CTD	Cisplatin results in increased expression of ATR protein modified form	PMID:26739623
Atr	increases phosphorylation	ISO	ATR (Homo sapiens)	6480464	CTD	Cisplatin results in increased phosphorylation of ATR protein	PMID:37802411
Atr	multiple interactions	ISO	Atr (Rattus norvegicus)	6480464	CTD	Lovastatin inhibits the reaction [Cisplatin results in increased expression of ATR protein modified form]	PMID:26739623
Atr	multiple interactions	ISO	ATR (Homo sapiens)	6480464	CTD	3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Cisplatin results in increased phosphorylation of ATR protein]; [4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine results in decreased activity of ATR] which results in increased susceptibility to Cisplatin; [ATR co-treated with TP53] results in decreased susceptibility to Cisplatin; Cisplatin promotes the reaction [MSH2 protein binds to and affects the localization of ATR protein]; ERCC6 protein inhibits the reaction [Cisplatin results in increased activity of ATR protein]; PTEN protein affects the reaction [Cisplatin results in increased phosphorylation of ATR protein]	PMID:21258400 PMID:21285353 PMID:21324906 PMID:21730979 PMID:37802411

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