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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1557770
Species: Mus musculus
RGD Object: Gene
Symbol: Camp
Name: cathelicidin antimicrobial peptide
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Campaffects localizationISOCAMP (Homo sapiens)6480464CTDCalcitriol affects the localization of CAMP proteinPMID:19748465
Campincreases expressionISOCAMP (Homo sapiens)6480464CTDCalcitriol results in increased expression of CAMP mRNA; Calcitriol results in increased expression of CAMP proteinPMID:15985530 PMID:18180267 PMID:19244278 PMID:19748465 PMID:22029407 PMID:22466564 PMID:24039193
Campincreases response to substanceISOCAMP (Homo sapiens)6480464CTDCAMP results in increased susceptibility to CalcitriolPMID:19748465
Campmultiple interactionsISOCAMP (Homo sapiens)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Calcitriol affects the localization of CAMP protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol promotes the reaction [Resveratrol results in increased expression of CAMP mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in increased expression of CAMP mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]]; [CAMP results in increased activity of CEBPB] affects the reaction [Calcitriol results in increased expression of ATG5 mRNA]; [CAMP results in increased activity of CEBPB] affects the reaction [Calcitriol results in increased expression of BECN1 mRNA]; [CAMP results in increased activity of MAPK14] affects the reaction [Calcitriol results in increased expression of ATG5 mRNA]; [CAMP results in increased activity of MAPK14] affects the reaction [Calcitriol results in increased expression of BECN1 mRNA]; [CAMP results in increased activity of MAPK1] affects the reaction [Calcitriol results in increased expression of ATG5 mRNA]; [CAMP results in increased activity of MAPK1] affects the reaction [Calcitriol results in increased expression of BECN1 mRNA]; [CAMP results in increased activity of MAPK3] affects the reaction [Calcitriol results in increased expression of ATG5 mRNA]; [CAMP results in increased activity of MAPK3] affects the reaction [Calcitriol results in increased expression of BECN1 mRNA]; AZD 6244 promotes the reaction [Calcitriol promotes the reaction [Resveratrol results in increased expression of CAMP mRNA]]; AZD 6244 promotes the reaction [Resveratrol promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]]; Calcitriol promotes the reaction [pterostilbene results in increased expression of CAMP mRNA]; Calcitriol promotes the reaction [pterostilbene results in increased expression of CAMP protein]; Calcitriol promotes the reaction [Resveratrol results in increased expression of CAMP mRNA]; Calcitriol promotes the reaction [Resveratrol results in increased expression of CAMP protein]; Calcitriol promotes the reaction [VDR protein binds to CAMP promoter]; CAMKK2 mutant form inhibits the reaction [Calcitriol affects the localization of CAMP protein]; CAMP mutant form inhibits the reaction [Calcitriol results in increased activity of MAPK1 protein]; CAMP mutant form inhibits the reaction [Calcitriol results in increased activity of MAPK14 protein]; CAMP mutant form inhibits the reaction [Calcitriol results in increased activity of MAPK3 protein]; CAMP mutant form inhibits the reaction [Calcitriol results in increased expression of ATG5 mRNA]; CAMP mutant form inhibits the reaction [Calcitriol results in increased expression of BECN1 mRNA]; CAMP mutant form inhibits the reaction [Calcitriol results in increased expression of CEBPB mRNA]; dorsomorphin inhibits the reaction [Calcitriol affects the localization of CAMP protein]; HR protein promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]; PRKAA1 mutant form inhibits the reaction [Calcitriol affects the localization of CAMP protein]; pterostilbene promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]; pterostilbene promotes the reaction [Calcitriol results in increased expression of CAMP protein]; Resveratrol promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]; Resveratrol promotes the reaction [Calcitriol results in increased expression of CAMP protein]; SB 203580 promotes the reaction [Calcitriol promotes the reaction [Resveratrol results in increased expression of CAMP mRNA]]; SB 203580 promotes the reaction [Resveratrol promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]]; STO 609 inhibits the reaction [Calcitriol affects the localization of CAMP protein]PMID:15985530 PMID:19748465 PMID:22466564 PMID:24039193
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