GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Krt18 | increases expression | EXP | | 6480464 | CTD | Estradiol results in increased expression of KRT18 mRNA | PMID:19484750 | Krt18 | decreases expression | ISO | Krt18 (Rattus norvegicus) | 6480464 | CTD | Estradiol results in decreased expression of KRT18 mRNA; Estradiol results in decreased expression of KRT18 protein | PMID:32145629 | Krt18 | decreases expression | ISO | KRT18 (Homo sapiens) | 6480464 | CTD | Estradiol results in decreased expression of KRT18 mRNA; Estradiol results in decreased expression of KRT18 protein | PMID:23019147 PMID:34719554 PMID:35044086 | Krt18 | increases expression | ISO | KRT18 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of KRT18 mRNA | PMID:11179685 PMID:19484750 | Krt18 | multiple interactions | ISO | KRT18 (Homo sapiens) | 6480464 | CTD | 3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of KRT18 mRNA]; AG 1879 inhibits the reaction [Estradiol results in decreased expression of KRT18 protein]; ESR1 protein alternative form promotes the reaction [Estradiol results in decreased expression of KRT18 protein]; KRT18 protein promotes the reaction [Fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of KRT18 mRNA] | PMID:11179685 PMID:20061804 PMID:35044086 | | ||||||||||||||||||||||
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