GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Irak1 | decreases expression | EXP | | 6480464 | CTD | Lipopolysaccharides results in decreased expression of IRAK1 mRNA | PMID:25890327 | Irak1 | increases activity | EXP | | 6480464 | CTD | Lipopolysaccharides results in increased activity of IRAK1 protein | PMID:21276822 | Irak1 | increases degradation | EXP | | 6480464 | CTD | Lipopolysaccharides results in increased degradation of IRAK1 protein | PMID:15933225 PMID:16678799 PMID:22849695 PMID:23902980 | Irak1 | increases expression | EXP | | 6480464 | CTD | Lipopolysaccharides results in increased expression of IRAK1 mRNA | PMID:25843059 | Irak1 | increases phosphorylation | EXP | | 6480464 | CTD | Lipopolysaccharides results in increased phosphorylation of IRAK1 protein | PMID:22849695 | Irak1 | multiple interactions | EXP | | 6480464 | CTD | 3,4-dihydroxybenzohydroxamic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IRAK1 mRNA]; [Lipopolysaccharides results in increased activity of IRAK1 protein] which results in increased phosphorylation of CHUK protein; [Lipopolysaccharides results in increased activity of IRAK1 protein] which results in increased phosphorylation of IKBKB protein; [Lipopolysaccharides results in increased activity of IRAK1 protein] which results in increased phosphorylation of TAK1 protein; Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein]; ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein]; ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRAK1 protein]; glutamyl-(2-(((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)carbonyl)-3-((2-(1H-indol-3-yl)ethyl)amino)-3-oxopropyl)-cysteinyl-glycine sodium salt inhibits the reaction [[Lipopolysaccharides results in increased activity of IRAK1 protein] which results in increased phosphorylation of CHUK protein]; glutamyl-(2-(((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)carbonyl)-3-((2-(1H-indol-3-yl)ethyl)amino)-3-oxopropyl)-cysteinyl-glycine sodium salt inhibits the reaction [[Lipopolysaccharides results in increased activity of IRAK1 protein] which results in increased phosphorylation of IKBKB protein]; helenalin inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein]; IRAK1 protein promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]; IRAK1 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of SMAD3 protein]; Lipopolysaccharides results in increased phosphorylation of and results in increased activity of IRAK1 protein; Lipopolysaccharides results in increased phosphorylation of and results in increased ubiquitination of and results in increased degradation of IRAK1 protein; Xanthones inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased ubiquitination of and results in increased degradation of IRAK1 protein] | PMID:16678799 PMID:19159680 PMID:21232528 PMID:21276822 PMID:21295571 PMID:22849695 PMID:25843059 | Irak1 | increases degradation | ISO | IRAK1 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in increased degradation of IRAK1 protein | PMID:17053167 | Irak1 | increases phosphorylation | ISO | IRAK1 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in increased phosphorylation of IRAK1 protein | PMID:17053167 | Irak1 | increases ubiquitination | ISO | IRAK1 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in increased ubiquitination of IRAK1 protein | PMID:30769083 | Irak1 | multiple interactions | ISO | IRAK1 (Homo sapiens) | 6480464 | CTD | kaempferol inhibits the reaction [Lipopolysaccharides results in increased ubiquitination of IRAK1 protein] | PMID:30769083 | Irak1 | multiple interactions | ISO | Irak1 (Rattus norvegicus) | 6480464 | CTD | [Lipopolysaccharides co-treated with Titanium] results in decreased expression of IRAK1 mRNA | PMID:21308757 | | ||||||||||||||||||||||
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