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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553791
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt2b1
Name: UDP glucuronosyltransferase 2 family, polypeptide B1
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt2b1increases expressionEXP 6480464CTDPhenobarbital results in increased expression of UGT2B1 mRNAPMID:19760798
Ugt2b1decreases expressionISOUGT2B17 (Homo sapiens)6480464CTDPhenobarbital results in decreased expression of UGT2B17 mRNAPMID:19084549
Ugt2b1increases activityISOUgt2b1 (Rattus norvegicus)6480464CTDPhenobarbital results in increased activity of UGT2B17 proteinPMID:8263600
Ugt2b1increases expressionISOUgt2b1 (Rattus norvegicus)6480464CTDPhenobarbital results in increased expression of UGT2B1 mRNA; Phenobarbital results in increased expression of UGT2B1 protein; Phenobarbital results in increased expression of UGT2B17 mRNAPMID:10036216 PMID:10476907 PMID:11328961 PMID:12832660 PMID:16408618 PMID:16940010 PMID:17381134 PMID:17967931 PMID:19162173 PMID:22037397 PMID:24090815 PMID:28520973 PMID:8263600
Ugt2b1multiple interactionsISOUgt2b1 (Rattus norvegicus)6480464CTDUGT2B17 protein affects the reaction [Phenobarbital results in increased abundance of Ascorbic Acid]PMID:8263600
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