GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Fgf8 | decreases expression | EXP | | 6480464 | CTD | Tretinoin results in decreased expression of FGF8 mRNA; Tretinoin results in decreased expression of FGF8 protein | PMID:12588859 PMID:14623956 PMID:17551590 | Fgf8 | multiple interactions | EXP | | 6480464 | CTD | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of FGF8 mRNA; CYP26A1 protein inhibits the reaction [Tretinoin results in decreased expression of FGF8 mRNA] | PMID:12588859 PMID:36189433 | Fgf8 | affects expression | ISO | FGF8 (Homo sapiens) | 6480464 | CTD | Tretinoin affects the expression of FGF8 mRNA | PMID:31600526 | Fgf8 | decreases expression | ISO | FGF8 (Homo sapiens) | 6480464 | CTD | Tretinoin results in decreased expression of FGF8 mRNA | PMID:21934132 | Fgf8 | multiple interactions | ISO | FGF8 (Homo sapiens) | 6480464 | CTD | [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of GFRA1 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of GLI1 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NEFL protein; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NEFM protein; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NR4A2 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NTRK1 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NTRK2 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of NTRK3 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of PTCH1 mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of RBFOX3 protein; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of SYP protein; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of TH mRNA; [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of TH protein | PMID:17085092 | | ||||||||||||||||||||||
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