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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553692
Species: Mus musculus
RGD Object: Gene
Symbol: Snai1
Name: snail family zinc finger 1
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Snai1increases expressionISOSNAI1 (Homo sapiens)6480464CTDNicotine results in increased expression of SNAI1 mRNA; Nicotine results in increased expression of SNAI1 proteinPMID:23219715
Snai1increases expressionISOSnai1 (Rattus norvegicus)6480464CTDNicotine results in increased expression of SNAI1 mRNA; Nicotine results in increased expression of SNAI1 proteinPMID:34245815
Snai1increases response to substanceISOSNAI1 (Homo sapiens)6480464CTDSNAI1 results in increased susceptibility to NicotinePMID:23219715
Snai1multiple interactionsISOSNAI1 (Homo sapiens)6480464CTDSNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of BMI1 mRNA]; SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of NANOG mRNA]; SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]PMID:23219715
Snai1multiple interactionsISOSnai1 (Rattus norvegicus)6480464CTDSNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 protein]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 protein]PMID:34245815
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