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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553412
Species: Mus musculus
RGD Object: Gene
Symbol: Angptl4
Name: angiopoietin-like 4
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Angptl4affects response to substanceEXP 6480464CTDANGPTL4 affects the susceptibility to DexamethasonePMID:19628874
Angptl4decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of ANGPTL4 mRNAPMID:22733784
Angptl4increases expressionEXP 6480464CTDDexamethasone results in increased expression of ANGPTL4 mRNAPMID:19628874
Angptl4increases response to substanceEXP 6480464CTDANGPTL4 gene mutant form results in increased susceptibility to DexamethasonePMID:31053639
Angptl4multiple interactionsEXP 6480464CTD[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ANGPTL4 mRNA; [ANGPTL4 gene mutant form results in increased susceptibility to Dexamethasone] which results in decreased expression of FASN mRNA; [ANGPTL4 gene mutant form results in increased susceptibility to Dexamethasone] which results in decreased expression of MLXIPL mRNA; [Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ANGPTL4 mRNA; [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ANGPTL4 mRNA]; ANGPTL4 gene mutant form inhibits the reaction [Dexamethasone results in decreased expression of ACACA mRNA]; ANGPTL4 gene mutant form inhibits the reaction [Dexamethasone results in decreased expression of ACACB mRNA]; ANGPTL4 gene mutant form inhibits the reaction [Dexamethasone results in decreased expression of AGPAT3 mRNA]; ANGPTL4 gene mutant form inhibits the reaction [Dexamethasone results in decreased expression of CD36 mRNA]; ANGPTL4 gene mutant form inhibits the reaction [Dexamethasone results in decreased expression of LPIN1 mRNA]; ANGPTL4 gene mutant form inhibits the reaction [Dexamethasone results in decreased expression of MLXIPL mRNA alternative form]; ANGPTL4 gene mutant form promotes the reaction [Dexamethasone results in decreased expression of SREBF1 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ANGPTL4 mRNA]PMID:16054899 PMID:23428407 PMID:31053639
Angptl4increases expressionISOAngptl4 (Rattus norvegicus)6480464CTDDexamethasone results in increased expression of ANGPTL4 mRNAPMID:20032058
Angptl4multiple interactionsISOAngptl4 (Rattus norvegicus)6480464CTDDexamethasone inhibits the reaction [Freund's Adjuvant results in decreased expression of ANGPTL4 mRNA]; Testosterone inhibits the reaction [Dexamethasone results in increased expression of ANGPTL4 mRNA]PMID:20032058 PMID:21149847
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