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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553412
Species: Mus musculus
RGD Object: Gene
Symbol: Angptl4
Name: angiopoietin-like 4
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Angptl4decreases expressionEXP 6480464CTDpirinixic acid results in decreased expression of ANGPTL4 mRNAPMID:16985257
Angptl4increases expressionEXP 6480464CTDpirinixic acid results in increased expression of ANGPTL4 mRNAPMID:16357043 PMID:17118139 PMID:17426115 PMID:18301758 PMID:18445702 PMID:23811191
Angptl4increases expressionISOANGPTL4 (Homo sapiens)6480464CTDpirinixic acid results in increased expression of ANGPTL4 mRNAPMID:23811191 PMID:27551952
Angptl4increases expressionISOAngptl4 (Rattus norvegicus)6480464CTDpirinixic acid results in increased expression of ANGPTL4 mRNAPMID:16940010 PMID:27665778 PMID:32741897 PMID:33983380
Angptl4multiple interactionsISOAngptl4 (Rattus norvegicus)6480464CTD[pirinixic acid results in increased activity of PPARA protein] which results in increased expression of ANGPTL4 mRNA; MDM2 protein promotes the reaction [[pirinixic acid results in increased activity of PPARA protein] which results in increased expression of ANGPTL4 mRNA]PMID:19103650
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