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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552719
Species: Mus musculus
RGD Object: Gene
Symbol: Ifnb1
Name: interferon beta 1, fibroblast
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifnb1increases response to substanceISOIFNB1 (Homo sapiens)6480464CTDIFNB1 protein results in increased susceptibility to FluorouracilPMID:15937643 PMID:16101138 PMID:18695887
Ifnb1multiple interactionsISOIFNB1 (Homo sapiens)6480464CTD[Fluorouracil co-treated with IFNB1 protein] results in increased activity of CASP3 proteinPMID:18608205
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