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GENE - TERM ANNOTATION REPORT

RGD ID: 1552631
Species: Mus musculus
RGD Object: Gene
Symbol: Skp2
Name: S-phase kinase-associated protein 2
Acc ID: GO:0019005
Term: SCF ubiquitin ligase complex
Definition: A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
Definition Source(s): PMID:15571813, PMID:15688063
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Skp2part_ofIBAPANTHER:PTN001923412 or MGI:1351663 or FB:FBgn0037236 or Fbxl22 (Rattus norvegicus) or UniProtKB:Q9UKT7 or MGI:2442921 or UniProtKB:Q9UF56 or TAIR:locus:2158824 or TAIR:locus:2125527 or UniProtKB:Q13309 or TAIR:locus:2099237 or TAIR:locus:2174398 or TAIR:locus:21359422290270GO_Central GO_REF:0000033
Skp2part_ofIDA 2290270MGI MGI:5438910 PMID:22464731 PMID:17785450

MGI:5438910 PMID:17785450 PMID:22464731
Skp2part_ofISOUniProtKB:Q133092290270MGI GO_REF:0000119 MGI:4834177
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