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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552629
Species: Mus musculus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:8077
Term: Phenoxybenzamine
Definition: An aromatic amine that has formula C18H22ClNO.
Chemical ID: MESH:D010643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3multiple interactionsISONR1I3 (Homo sapiens)6480464CTDPhenoxybenzamine binds to and results in increased activity of NR1I3 protein alternative form; Phenoxybenzamine inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; Phenoxybenzamine promotes the reaction [NCOA1 protein binds to NR1I3 protein]; Phenoxybenzamine promotes the reaction [NCOA3 protein binds to NR1I3 protein]PMID:31312845
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