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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552629
Species: Mus musculus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:79516
Term: Nonylphenol
Definition: null
Chemical ID: MESH:C025256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3multiple interactionsEXP 6480464CTDnonylphenol affects the reaction [NR1I3 affects the susceptibility to Zoxazolamine]; nonylphenol binds to and results in increased activity of NR1I3 protein; nonylphenol inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; NR1I3 affects the reaction [nonylphenol results in decreased expression of CYP2C40 mRNA]; NR1I3 gene mutant form affects the reaction [nonylphenol results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form affects the reaction [nonylphenol results in increased expression of CYP2C29 mRNA]; NR1I3 gene mutant form affects the reaction [nonylphenol results in increased expression of CYP3A11 mRNA]PMID:18832183 PMID:19041682
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