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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552455
Species: Mus musculus
RGD Object: Gene
Symbol: Fas
Name: Fas cell surface death receptor
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fasincreases expressionISOFAS (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of FAS; Arsenic Trioxide results in increased expression of FAS mRNA; Arsenic Trioxide results in increased expression of FAS proteinPMID:11135700 PMID:12126518 PMID:12452020 PMID:12478894 PMID:12684647 PMID:12975549 PMID:15382040 PMID:15979894 PMID:16029599 PMID:17530438 PMID:20819644 PMID:24356939 PMID:27430728 PMID:34953944
Fasincreases response to substanceISOFAS (Homo sapiens)6480464CTDFAS results in increased susceptibility to Arsenic TrioxidePMID:12684647
Fasmultiple interactionsISOFAS (Homo sapiens)6480464CTD[Arsenic Trioxide co-treated with Curcumin] results in increased expression of FAS protein; [sanguinarine co-treated with Arsenic Trioxide] results in increased expression of FAS mRNA; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of FAS protein]; FAS protein affects the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]; FAS protein affects the reaction [Arsenic Trioxide results in increased cleavage of CASP8 protein]; FAS protein affects the reaction [Arsenic Trioxide results in increased expression of FADD protein]; FAS protein affects the reaction [Arsenic Trioxide results in increased expression of FAS protein]; FAS protein affects the reaction [Arsenic Trioxide results in increased expression of FASLG protein]; NFKBIA protein inhibits the reaction [Arsenic Trioxide results in increased expression of FAS protein]PMID:15382040 PMID:24345465 PMID:27430728 PMID:34953944
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