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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552455
Species: Mus musculus
RGD Object: Gene
Symbol: Fas
Name: Fas cell surface death receptor
Acc ID: CHEBI:4911
Term: etoposide
Definition: A furonaphthodioxole that has formula C29H32O13.
Chemical ID: MESH:D005047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fasincreases expressionEXP 6480464CTDEtoposide results in increased expression of FAS mRNAPMID:12513834
Fasincreases expressionISOFAS (Homo sapiens)6480464CTDEtoposide results in increased expression of FAS mRNA; Etoposide results in increased expression of FAS proteinPMID:16192531 PMID:29397400
Fasmultiple interactionsISOFAS (Homo sapiens)6480464CTD3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Etoposide results in increased expression of and affects the localization of FAS protein]; Etoposide results in increased expression of and affects the localization of FAS protein; Lithium inhibits the reaction [Etoposide results in increased expression of and affects the localization of FAS protein]PMID:15475000
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