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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552455
Species: Mus musculus
RGD Object: Gene
Symbol: Fas
Name: Fas cell surface death receptor
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fasincreases expressionISOFAS (Homo sapiens)6480464CTDCyclosporine results in increased expression of FAS mRNAPMID:20106945 PMID:25596134
Fasmultiple interactionsISOFAS (Homo sapiens)6480464CTDCyclosporine inhibits the reaction [FAS protein results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [FAS protein results in increased activity of CASP8 protein]; Cyclosporine inhibits the reaction [FAS protein results in increased activity of CASP9 protein]PMID:15548389
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