Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552455
Species: Mus musculus
RGD Object: Gene
Symbol: Fas
Name: Fas cell surface death receptor
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fasincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of FAS mRNAPMID:19770486 PMID:21569818 PMID:21715664 PMID:22228805
Fasaffects expressionISOFAS (Homo sapiens)6480464CTDBenzo(a)pyrene affects the expression of FAS mRNAPMID:21873647
Fasdecreases expressionISOFAS (Homo sapiens)6480464CTDBenzo(a)pyrene metabolite results in decreased expression of FAS mRNAPMID:24356939
Fasdecreases expressionISOFas (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in decreased expression of FAS proteinPMID:21467743
Fasdecreases methylationISOFAS (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of FAS promoterPMID:27901495
Fasincreases expressionISOFAS (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of FAS mRNA; Benzo(a)pyrene results in increased expression of FAS proteinPMID:16041517 PMID:20064835 PMID:20106945 PMID:21632981 PMID:21871943 PMID:22316170 PMID:22889811 PMID:26238291 PMID:32234424
Fasmultiple interactionsISOFAS (Homo sapiens)6480464CTDNitrogen Oxides inhibits the reaction [Benzo(a)pyrene results in increased expression of FAS protein]PMID:16041517
Go Back to source page   Continue to Ontology report