Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	1552430
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Clock
Name:	clock circadian regulator

Acc ID:	CHEBI:33216
Term:	bisphenol A
Definition:	A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID:	MESH:C006780

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Clock	affects methylation	EXP		6480464	CTD	bisphenol A affects the methylation of CLOCK promoter	PMID:27334623
Clock	increases expression	EXP		6480464	CTD	bisphenol A results in increased expression of CLOCK mRNA	PMID:33221593
Clock	multiple interactions	EXP		6480464	CTD	[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of CLOCK mRNA	PMID:28433925
Clock	affects expression	ISO	Clock (Rattus norvegicus)	6480464	CTD	bisphenol A affects the expression of CLOCK mRNA	PMID:25181051
Clock	increases expression	ISO	Clock (Rattus norvegicus)	6480464	CTD	bisphenol A results in increased expression of CLOCK mRNA	PMID:30816183
Clock	increases methylation	ISO	Clock (Rattus norvegicus)	6480464	CTD	bisphenol A results in increased methylation of CLOCK gene	PMID:28505145

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