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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552419
Species: Mus musculus
RGD Object: Gene
Symbol: Map2k6
Name: mitogen-activated protein kinase kinase 6
Acc ID: CHEBI:75832
Term: iron(2+) sulfate (anhydrous)
Definition: A compound of iron and sulfate in which the ratio of iron(2+) to sulfate ions is 1:1. Various hydrates occur naturally - most commonly the heptahydrate, which loses water to form the tetrahydrate at 57degreeC and the monohydrate at 65degreeC.
Chemical ID: MESH:C020748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k6increases phosphorylationISOMap2k6 (Rattus norvegicus)6480464CTDferrous sulfate results in increased phosphorylation of MAP2K6 proteinPMID:17172471
Map2k6multiple interactionsISOMap2k6 (Rattus norvegicus)6480464CTDferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]; Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAP2K6 protein]PMID:17172471
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