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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552258
Species: Mus musculus
RGD Object: Gene
Symbol: Hbegf
Name: heparin-binding EGF-like growth factor
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hbegfmultiple interactionsEXP 6480464CTD[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of HBEGF mRNAPMID:30529165
Hbegfmultiple interactionsISOHBEGF (Homo sapiens)6480464CTDOxygen deficiency promotes the reaction [HBEGF protein mutant form results in increased activity of CASP3 protein]; Oxygen deficiency promotes the reaction [HBEGF protein mutant form results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Oxygen deficiency promotes the reaction [HBEGF protein mutant form results in increased activity of CASP3 protein]]PMID:19193634
Hbegfmultiple interactionsISOHbegf (Rattus norvegicus)6480464CTD[Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in increased expression of HBEGF mRNAPMID:33729688
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