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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552054
Species: Mus musculus
RGD Object: Gene
Symbol: Adipoq
Name: adiponectin, C1Q and collagen domain containing
Acc ID: CHEBI:79989
Term: GW 6471
Definition: An amphetamine that has formula C35H36F3N3O5.
Chemical ID: MESH:C449302
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adipoqdecreases expressionEXP 6480464CTDGW 6471 results in decreased expression of ADIPOQ mRNAPMID:21324916
Adipoqmultiple interactionsEXP 6480464CTDGW 6471 inhibits the reaction [[GW 7647 co-treated with PPARA protein] results in increased expression of ADIPOQ mRNA]; GW 6471 inhibits the reaction [ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]]; GW 6471 inhibits the reaction [ADIPOQ protein promotes the reaction [[PPARA protein binds to HMOX1 promoter] which results in increased expression of HMOX1 mRNA]]; GW 6471 inhibits the reaction [ADIPOQ protein results in increased expression of and results in increased activity of HMOX1 protein]; GW 6471 inhibits the reaction [ADIPOQ protein results in increased expression of BCL2L1 protein]PMID:20709802 PMID:21324916
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