GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pfkfb4 | increases expression | ISO | PFKFB4 (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in increased expression of PFKFB4 mRNA; Oxygen deficiency results in increased expression of PFKFB4 protein | PMID:16025159 PMID:24236059 PMID:24403227 PMID:25596134 PMID:26516004 PMID:27292261 | Pfkfb4 | multiple interactions | ISO | PFKFB4 (Homo sapiens) | 6480464 | CTD | 1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of PFKFB4 mRNA]; Oxygen deficiency promotes the reaction [HIF1A protein results in increased expression of PFKFB4 mRNA] | PMID:16025159 PMID:24403227 | |
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