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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552027
Species: Mus musculus
RGD Object: Gene
Symbol: Ep300
Name: E1A binding protein p300
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ep300decreases expressionISOEP300 (Homo sapiens)6480464CTDGenistein results in decreased expression of EP300 mRNAPMID:30684530
Ep300increases expressionISOEP300 (Homo sapiens)6480464CTDGenistein results in increased expression of EP300 proteinPMID:26768552
Ep300multiple interactionsISOEP300 (Homo sapiens)6480464CTDEP300 promotes the reaction [Genistein promotes the reaction [trichostatin A results in increased expression of TP53 mRNA]]; EP300 promotes the reaction [Genistein promotes the reaction [trichostatin A results in increased expression of TP53 protein]]; Genistein inhibits the reaction [EP300 protein binds to COMT promoter]; trichostatin A promotes the reaction [Genistein results in increased expression of EP300 protein]PMID:26768552 PMID:30684530
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