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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551988
Species: Mus musculus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase family, member 1
Acc ID: CHEBI:78741
Term: oxidopamine
Definition: A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Chemical ID: MESH:D016627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases cleavageEXP 6480464CTDOxidopamine results in increased cleavage of PARP1 proteinPMID:10397638 PMID:33571554
Parp1multiple interactionsEXP 6480464CTD2-chloro-5-hydroxyphenylglycine affects the reaction [Oxidopamine results in increased cleavage of PARP1 protein]; 6-methyl-2-(phenylethynyl)pyridine promotes the reaction [Oxidopamine results in increased cleavage of PARP1 protein]; GOPC protein affects the reaction [2-chloro-5-hydroxyphenylglycine affects the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; GOPC protein affects the reaction [6-methyl-2-(phenylethynyl)pyridine promotes the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; GOPC protein affects the reaction [Oxidopamine results in increased cleavage of PARP1 protein]PMID:33571554
Parp1increases activityISOParp1 (Rattus norvegicus)6480464CTDOxidopamine results in increased activity of PARP1 proteinPMID:21397656
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDOxidopamine results in increased cleavage of PARP1 proteinPMID:25446857 PMID:30707903 PMID:31705926
Parp1increases cleavageISOParp1 (Rattus norvegicus)6480464CTDOxidopamine results in increased cleavage of PARP1 proteinPMID:25446857
Parp1increases expressionISOPARP1 (Homo sapiens)6480464CTDOxidopamine results in increased expression of PARP1 proteinPMID:31176653
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTDOPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; pyrazolanthrone inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]; salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]; SB 203580 inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]; TH protein inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]; tricetin inhibits the reaction [Oxidopamine results in increased expression of PARP1 protein]PMID:19815691 PMID:25446857 PMID:30707903 PMID:31176653 PMID:31705926
Parp1multiple interactionsISOParp1 (Rattus norvegicus)6480464CTD5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Oxidopamine results in increased activity of PARP1 protein]; salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]PMID:21397656 PMID:25446857
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