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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551973
Species: Mus musculus
RGD Object: Gene
Symbol: Odc1
Name: ornithine decarboxylase, structural 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Odc1increases activityISOODC1 (Homo sapiens)6480464CTDParaquat results in increased activity of ODC1 proteinPMID:7662713
Odc1increases expressionISOOdc1 (Rattus norvegicus)6480464CTDParaquat results in increased expression of ODC1 mRNAPMID:32680482
Odc1multiple interactionsISOODC1 (Homo sapiens)6480464CTDCAT protein inhibits the reaction [Paraquat results in increased activity of ODC1 protein]; Cycloheximide inhibits the reaction [Paraquat results in increased activity of ODC1 protein]; Dimethyl Sulfoxide inhibits the reaction [Paraquat results in increased activity of ODC1 protein]; tempol inhibits the reaction [Paraquat results in increased activity of ODC1 protein]PMID:7662713
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