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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551432
Species: Mus musculus
RGD Object: Gene
Symbol: Oprm1
Name: opioid receptor, mu 1
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Oprm1decreases expressionEXP 6480464CTDMethamphetamine results in decreased expression of OPRM1 mRNA; Methamphetamine results in decreased expression of OPRM1 proteinPMID:21886566
Oprm1multiple interactionsEXP 6480464CTDFluoxetine inhibits the reaction [Methamphetamine results in decreased expression of OPRM1 mRNA]; Fluoxetine inhibits the reaction [Methamphetamine results in decreased expression of OPRM1 protein]; OPRM1 protein affects the susceptibility to [Methamphetamine results in decreased expression of TH mRNA]; OPRM1 protein affects the susceptibility to [Methamphetamine results in decreased expression of TH protein]; OPRM1 protein inhibits the reaction [Haloperidol inhibits the reaction [Methamphetamine results in increased expression of EGR1 mRNA]]PMID:20184921 PMID:21886566 PMID:22329540
Oprm1increases expressionISOOprm1 (Rattus norvegicus)6480464CTDMethamphetamine results in increased expression of OPRM1 mRNAPMID:15644446
Oprm1increases response to substanceISOOPRM1 (Homo sapiens)6480464CTDOPRM1 gene SNP results in increased susceptibility to MethamphetaminePMID:16402083
Oprm1multiple interactionsISOOprm1 (Rattus norvegicus)6480464CTD[CTAP octapeptide binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to MethamphetaminePMID:20298714
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