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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551311
Species: Mus musculus
RGD Object: Gene
Symbol: Prss23
Name: serine protease 23
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prss23decreases expressionISOPRSS23 (Homo sapiens)6480464CTDEstradiol results in decreased expression of PRSS23 mRNAPMID:19167446 PMID:23019147
Prss23increases expressionISOPRSS23 (Homo sapiens)6480464CTDEstradiol results in increased expression of PRSS23 mRNAPMID:15913882 PMID:19619570 PMID:20049119 PMID:21185374 PMID:23384675 PMID:24758408 PMID:26865669 PMID:28711546 PMID:31614463
Prss23multiple interactionsISOPRSS23 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PRSS23 mRNA; [Estradiol co-treated with TGFB1 protein] results in increased expression of PRSS23 mRNA; EGF protein promotes the reaction [Estradiol results in increased expression of PRSS23 mRNA]; ESR1 protein inhibits the reaction [Estradiol results in increased expression of PRSS23 mRNA]; methoxyacetic acid inhibits the reaction [Estradiol results in increased expression of PRSS23 mRNA]PMID:19619570 PMID:20049119 PMID:23384675 PMID:24758408 PMID:30165855
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