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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551095
Species: Mus musculus
RGD Object: Gene
Symbol: Rela
Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaaffects localizationEXP 6480464CTDCyclosporine affects the localization of RELA proteinPMID:23958496
Relamultiple interactionsEXP 6480464CTD7-oxozeanol inhibits the reaction [Cyclosporine affects the localization of RELA protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Cyclosporine affects the localization of RELA protein]; Cyclosporine results in increased phosphorylation of and affects the localization of RELA protein; pyrazolanthrone inhibits the reaction [Cyclosporine affects the localization of RELA protein]PMID:23958496
Relaaffects localizationISORela (Rattus norvegicus)6480464CTDCyclosporine affects the localization of RELA proteinPMID:25772258
Relaincreases expressionISORELA (Homo sapiens)6480464CTDCyclosporine results in increased expression of RELA mRNAPMID:20106945
Relaincreases expressionISORela (Rattus norvegicus)6480464CTDCyclosporine results in increased expression of RELA proteinPMID:19391111
Relaincreases phosphorylationISORELA (Homo sapiens)6480464CTDCyclosporine results in increased phosphorylation of RELA proteinPMID:22343435
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDcobaltous chloride inhibits the reaction [Cyclosporine results in increased phosphorylation of RELA protein]PMID:22343435
Relamultiple interactionsISORela (Rattus norvegicus)6480464CTD3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Cyclosporine affects the localization of RELA protein]; Ascorbic Acid inhibits the reaction [Cyclosporine results in increased expression of RELA protein]; Cyclosporine inhibits the reaction [[Adenosine Triphosphate results in increased expression of NOS2 protein] promotes the reaction [NOS2 protein binds to RELA protein]]; S-allylcysteine inhibits the reaction [Cyclosporine results in increased expression of RELA protein]; SB 203580 inhibits the reaction [Cyclosporine affects the localization of RELA protein]; U 0126 inhibits the reaction [Cyclosporine affects the localization of RELA protein]PMID:19391111 PMID:21464294 PMID:25772258
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